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Building on this concept, researchers developed a 55-gene signature, referred to as the FERscore (Hu et al., 2024), specifically designed to predict the susceptibility of breast cancer to ferroptosis

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Baseline Assessment Before Starting ALA Before adding ALA at any dose to a rosuvastatin regimen, obtain or review: Fasting plasma glucose and HbA1c (to characterize baseline glycemic status) TSH (to rule out pre-existing hypothyroidism that could worsen) Creatine kinase (to document a baseline in case myalgia develops and thyroid effects are later implicated) Ongoing Monitoring by Dose At ALA doses of 300 mg/day or below in normoglycemic patients, no additional monitoring beyond routine statin follow-up is required

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