Loss of SLC7A11 results in lysosomal hyperacidity and labile iron release, sensitizing cells to ferroptosis
Altered decidual natural killer cells activity can lead to defective spiral artery remodeling and poor placental development, contributing to RM ( 5.3 Evidence of ferroptosis in RM pathophysiology Emerging studies support the involvement of ferroptosis in RM, highlighting its potential role in pathophysiology through various lines of evidence
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Consequently, Dihexa remains a subject of interest within research environments that emphasize documentation, repeatability, and standardized evaluation procedures
This is because though cobalamin will take a couple of weeks to reach appropriate levels in the body, especially if deficient, it can last in the body for a long time once it reaches appropriate concentrations
Note: some secondary sources cite the 2018 Neelakantan Biochem Pharmacol paper under differing PMIDs (29155147 vs 29355482)