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Most subsequent authors have agreed with this statement [7, 8]

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Lactic acidosis portends a poor prognosis (by Kings College Hospital (KCH) criteria), and the mechanism of lactic acidemia is two-fold: NAPQI being present in excess and causing mitochondrial dysregulation, followed in subsequent hours by tissue hypoxia and decreased hepatic metabolism and clearance of lactate, leading to a two-hit effect on worsening of the lactic acidosis condition

Luciferase is not an ingredient in any of the COVID-19 vaccines, but it has been used in past to visually see how viruses and vaccines interact with cells in the lab