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These putative direct targets include the mitochondria-localized isoform of glycerol-3-phosphate dehydrogenase (encoded by the GPD2 gene), the mitochondria-localized isoform of serine hydroxymethyltransferase (encoded by the SHMT2 gene), presenilin enhancer, gamma-secretase subunit (commonly identified as PEN2

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Further, the in vivo significance of the identified modifications remains in many cases to be established

Regulation of antioxidant defence systems

Variants in CFTR untranslated regions are associated with congenital bilateral absence of the vas deferens

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