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Overexpression of HIF-2 decreases GPX4 levels and facilitates the activity of carnitine palmitoyltransferase 1A (CPT1A), which transports fatty acids into the mitochondrial matrix for -oxidation, thus aggravating cartilage degeneration (Zhou et al., 2021)

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HFpEF exhibits more complexity and has more associated-comorbidities including hypertension compared to HFrEF, and systemic inflammation and its-induced metabolic injury are closely associated with the pathogenesis of HFpEF