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However, under cellular conditions, the concentration (110 mM) of GSH is several folds higher than of hydroperoxides (10100 M), and thus, the velocity ( V max ) of the detoxification of hydroperoxides by seleno-GPxs is practically independent of the concentration of GSH [8, 17, 18]

p53 inhibition group (p53 /): Trophoblast cells were co-cultured with the p53 inhibitor MG-132 for 48 h

This shift is coupled to significant changes in mitochondrial morphology, reactive oxygen species (ROS) production, and metabolically driven epigenetic changes that ultimately determine NSC/NPC fate (Figure 2)

doi:10.1007/s00167-009-0953-3

References Raun K, Hansen BS, Johansen NL, Thgersen H, Madsen K, Ankersen M, Andersen PH

Barnhill, K., et al