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Fisher himself acknowledge that it would be impossible to conduct a randomized control trial on smoking

Nicotine may temporarily relieve stress, but over time, dependence can lead to mood swings and irritability

Cigarette carton size A carton holds 10 packs of cigarettes

This addiction primarily stems from the presence of nicotine, a potent psychoactive substance found in tobacco, according to an article by the Center of Addiction and Mental Health titled Nicotine Dependence. The addictive nature of tobacco leads individuals to develop a tolerance, necessitating higher amounts to achieve the same effects, ultimately reinforcing the cycle of dependence