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The renal or extrarenal expression of 1--hydroxylase (CYP27B1) enzymatic action converts 25(OH)VD 3 to an active metabolite 1,25-dihydroxy vitamin D 3 (1,25(OH) 2 VD 3) 13

Some nonselective agonists can positively influence obesity and type 2 diabetes by modulating cellular signaling pathways that affect energy metabolism and fat accumulation [257, 258]

Guo X, Zhu Y, Hong X, Zhang M, Qiu X, Wang Z, et al