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The culture medium was then removed after 24 hours incubation

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64 In addition to ROS, electrophilic molecules engage the antioxidant system consisting of low molecular weight cellular antioxidants (e.g., GSH, vitamins C and E, thioredoxin, glutaredoxin, etc.), enzymes (e.g., glutathione-s-transferases (GSTs), superoxide dismutase (SOD), catalase, etc.), and cofactors (NAD + /NADH and NADP + /NADPH)

It effectively induces ferroptosis through mechanisms involving GPX4 degradation, lipid peroxidation, and lysosomal membrane permeabilization

ZZ: Investigation, Methodology, Writing original draft