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This was associated with reduced expression of xCT (the catalytic subunit of Sxc ) and mGlu2 receptors [116], suggesting that a defective endogenous activation of mGlu2 receptors in the nucleus accumbens underlies the altered glutamate homeostasis that is ultimately responsible for the loss of control in drug-seeking behavior and relapse

To investigate the relationship between the accumulation of LD and the altered proteins, we transfected the expression plasmid into HepG2 cells

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