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For in vivo experiments, both male and female mice were exposed to one puff of nicotine or cannabidiol aerosols for five days a week

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and 8:30 a.m.) in a state of abstention from food for the collection of saliva specimens, where they were also instructed to refrain from cigarette and e-cigarette smoking the night before (approximately 10 h without nicotine exposure) [12]

[The tobacco companies] have known many of these facts for at least 50 years or more

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