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euphoria , sedation , muscle relaxation, hypotension , bradycardia , & decreased perception of pain It may also affect 1 adrenergic, histamine, serotonin, and opioid receptors (Hoffman et al, 2001

In addition to common human diseases, such as cancer and neurogenerative diseases, GPX4 has been implicated in spermatogenesis and the pathogenesis of the rare genetic disease SSMD, as its mutation or downregulation reduces enzymatic activity

(2) enhanced aromatase activity in adipose tissue, leading to increased local and systemic estrogen levels, thereby stimulating pituitary prolactinocytes to synthesize and secrete prolactin

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The initial in vivo assessment for safety and toxicological effects showed it to be well tolerated on models of rat, monkey and dog [1]

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