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Update of cell damage mechanisms in thiamine deficiency: focus on oxidative stress, excitotoxicity and inflammation

A also stimulates the activation of NADPH oxidases (NOXs), integrin Iib-3, and ROS, promoting platelet adhesion, increasing levels of the endogenous inhibitors plasminogen activator inhibitor-1 and endothelin-1 (ET-1), and resulting in thrombosis, capillary constriction, and impaired blood flow [99, 181, 182]

Vitamin C can be used as a combination therapy with radiotherapy

BPC-157 upregulates VEGFR2 signalling, the same pathway many tumors depend on for blood supply

These competing interests did not affect the experimental design, data acquisition, data analysis or interpretation of the results presented in this paper

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