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Clinically, non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of RA are achieved by inhibiting COX to inhibit the expression of PGE2

At the level of functional regulation, current strategies include using TREM1 inhibitors to suppress M1 polarization or promoting M2 polarization through IL-4/IL-13-loaded nanoparticles (87)

Besides the thiol group, each GSH molecule also contains amine and carboxylate functionalities that provide coupling possibilities for further cross-linking to other molecules of biological or sensing interest

Over time, glutathione levels decrease due to age, poor diet, stress, illness, or environmental factors

Enhancing Glutathione's Effects