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PubMed DOI Canapp SO, Farese JP, Schultz GS, et al
Biofilm cells also remodel the components of their plasma membrane lipid composition and cell wall architecture, which contribute to physical and biochemical changes that reduce drug uptake or increase tolerance to membrane-directed stress ( Metabolic variation in biofilms, including areas of nutrient limitation, oxygen gradients, and slow-growing or metabolically quiescent subpopulations, plays a crucial role in determining the efficacy of drugs
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