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Phase Dual escalation 1 Weeks 13-16 Tirzepatide 7.5 mg/week Cagrilintide 0.5 mg/week Notes GI side effects often peak here

Since 90% of the bodys serotonin originates in the gut, modulating enteric serotonin production could influence central serotonergic tone through vagal afferents that relay gut signals to brain serotonin-producing raphe nuclei

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