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Inadequate dietary folate supply and/or gene polymorphisms of the remethylation enzymes may compromise the function of methionine/homocysteine circle with subsequent elevation of plasma homocysteine levels, and reduced methyl group generation for transmethylation reaction that may be associated with adverse clinical consequences [17,18,19]

First, however, it's important to keep in mind the axiom, 'If a little is good, a lot is not necessarily better.' Even basic substances required for life can be overdosed or underdosed, contributing to harmful life-threatening consequences

24 , 13561367.e1358 (2017)

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The only renal-related biomarkers were urine and serum creatinine that also were no affected by vitamin E exposure