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doi: 10.1093/hmg/ddu542

Hercules, CA) for 10 minutes

Exendin-4 increases bone mineral density in type 2 diabetic OLETF rats potentially through the down-regulation of SOST/sclerostin in osteocytes

Full IGF-1 receptor agonism Binds and activates the IGF-1 receptor identically to native IGF-1, but at higher effective concentrations because the free fraction is higher

The activation of this receptor induces a signal transducer and an activator of transcription 3 (STAT3)-dependent transcriptional activation of proinflammatory mediators, aggravating neuroinflammation

Palma FR, He C, Danes JM, Paviani V, Coelho DR, Gantner BN, et al