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Graham D, Huynh NN, Hamilton CA, Beattie E, Smith RA, Cochem HM, et al

In Nrf2 knockout rats, the constitutive activity of the choroidal glutathione-dependent detoxifying machinery is maintained, but the efficacy of dimethylfumarate to induce glutathione conjugation in the choroid plexuses is strongly reduced, indicating that dimethylfumarate acts mainly through the Nrf2 signaling pathway

doi: 10.2164/jandrol.108.006148 53 ChainyGSamantaraySSamantaL

Zinc oxide has astringent properties (causes contraction when applied to the skin), which help to shrink swelling

Subsequently, HQ has been banned for the general use by the European Committee and can be prescribed by dermatologists only 13,16