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It is anticipated that the development of a universal influenza vaccine will be an iterative process informed by continued studies into vaccine and natural infection correlates of protection
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Studies have examined NNMT inhibition in relation to cellular methylation balance, NAD metabolism, and broader metabolic signaling pathways
A rather simple but very effective method of removing dominant epitopes to enhance responses to conserved subdominant epitopes involved the removal of the S1 portion of spike containing the RBD and then the administration of a vaccine with only S2 as a DNA vaccine or protein [73] (Table 2)
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