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For instance, medicinal plant extracts have been tested for their metal chelating activities, with results showing concentration-dependent chelation capabilities

Subsequent work revealed that GSH contributed to gliotoxin sensitivity, since diamide, a GSH scavenger, was less toxic to A

doi: 10.1074/jbc.273.52.35299 22 ImSSYousefLBlaschitzCLiuJZEdwardsRAYoungSGet al

Indeed, one study has shown that administrating Kuppfer cells with t -butyl hydroperoxide, a substrate for glutathione peroxidase, inhibited the production of superoxide (59), which implied that the increased activity of the antioxidative pathway limits the availability of NADPH for the use by oxidative pathways (58)

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Normal rabbit IgG (#I8410, Sigma) was used as a non-specific antibody control