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Besides their significance in the overall copper efflux and balance, ATP7A and ATP7B play a critical role in copper transport between intracellular compartments

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The report was uncontrolled, unblinded, not randomized, had no comparator arm, used patient-reported outcomes rather than validated pain instruments, and did not publish dose, effect size, confidence intervals, p-values, or systematically collected adverse events limitations that severely constrain any clinical inference