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The interaction between immune components and the gut microbiota is pivotal in the function of the gut-brain-kidney axis, influencing the occurrence and development of other diseases such as inflammatory bowel diseases (IBD), vascular inflammation and cardiovascular diseases, tumors, obesity and metabolic syndrome, nervous system diseases, infectious diseases, and hepatic fibrosis (Wiredu Ocansey et al., 2023)

Studies also found that the high expression of MTHFD2 is correlated with the migration and invasiveness of breast cancer cells and is associated with a poor prognosis in breast cancer [105,106]

doi: 10.1104/pp.109.135228

Furthermore, metformin-induced 2-DG uptake decreased in cells overexpressing TXNIP compared with that in nonoverexpressing cells (Fig

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