This can result from chronic oxidative stress, heavy metal toxicity (especially iron overload), persistent infections, nutrient insufficiencies (sulfur amino acids, glycine, glutamate, selenium, B-vitamins), liver dysfunction, metabolic stress, and genetic polymorphisms in key enzymes like glutamate-cysteine ligase (GCL) or glutathione S-transferases (GSTs)
As shown in Figure 1, the concept of a gut-thyroid axis provides a compelling framework for understanding these interactions (Virili et al., 2024
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No matter what a fad diet or product may promise, the fact is that weight loss comes with burning more calories than you take in, so diet and exercise are the main keys to success if you want to lose weight
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