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Curcumin induced the HO-1 promoter by 36 and 300% in MIN6 and SK-N-MC cells, respectively, at concentrations present in the maximum dose of Protandim

In the presence of metals, especially iron and copper, and oxygen, ascorbic acid is oxidized to dehydroascorbate, which produces hydrogen peroxide and metal is reduced

Naunyn Schmiedebergs Arch Pharmacol 2014;387:95561

Many patients may be able to restart treatment after medical evaluation, depending on their health status and treatment goals

Serum paracetamol was lower in patients with side-effects than in those without (Mann-Whitney: P = 0.00006)