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Another aspect of slowing disease progression of ALS could be through protection of the BBB, but this warrants further investigation

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pmc.ncbi.nlm.nih.gov/articles/PMC6073405 Pickart L, Vasquez-Soltero JM, Margolina A

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More frequent stamping does not accelerate collagen synthesis (which follows its own schedule regardless of stimulation frequency) and degrades barrier function