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By mediating the transcription of crucial antioxidative enzymes, FOXO4 may help mitigate oxidative stress and maintain cellular integrity and function during episodes of high oxidative load or inflammation

Audo, R

Another potential therapeutic approach is the combination of CAR-T cell therapy with cholesterol-lowering drugs

499 Sareptas SRP-5051, an ASO conjugated with a targeting peptide, has shown higher levels of dystrophin expression and exon skipping rates than eteplirsen

The rationale is mechanistic (complementary pathways with no known antagonism) and supported by clinical experience from physicians who prescribe both

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