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This consideration explains why, under excess H 2 O 2 , cells with an initially higher GSH concentration display a faster GSH oxidation

Supports antioxidant activity*

Cytosol Extracellular matrix Mitochondrial matrix Peroxisomes Correct Answer: Mitochondrial matrix Q24

10.1083/jcb.152.5.1057 J

Following treatment (20 M, 3 days), significant demethylation and mRNA re-expression of WIF1 were observed, with this effect being especially pronounced with BDMC at lower doses

The intracellular glutamate concentration is nearly 10-fold higher than the Km value, but intracellular cysteine concentrations approximate the apparent Km value [10] indicating that cysteine may be a limiting substrate for GCL