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In addition, mtDNA mutations are also associated with abnormal mitochondrial ETC separation, reduced energy supply, and increased ROS production, which has been validated in the treatment of cardiovascular diseases (25)

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J Biol Chem 275:1553515540 Suzuki H, Kumagai H, Tochikura T (1986) Gamma-glutamyltranspeptidase from Escherichia coli K-12: formation and localization

Superoxide is rapidly converted into hydrogen peroxide (HO), by superoxide dismutase [27]

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