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Tobacco smokers have an increased risk of lung cancer, coronary artery disease and asthma.

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This phenomenon is well described and summarized in a paper by Nora Volkow, titled: Decreased Reward Sensitivity and Increased Expectation Sensitivity Conspire to Overwhelm the Brains Control Circuit. The counteradaptation model postulates that the initial positive feelings of reward resulting from the use of a drug are followed by an opposing rather than synchronous development of tolerance that is manifested by the appearance of withdrawal associated with the lack of the substance

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