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Although tachyphylaxis to this effect may occur with long-acting GLP-1 receptor agonists, GLP-1-associated slowing of gastric emptying does not appear to be responsible for the nausea and vomiting often reported with the use of GLP-1 receptor agonist treatment

This makes it a focal point of interest in studies related to cognitive decline, neuroplasticity, and hepatocyte growth factor (HGF) modulation

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Inagaki N, Seino Y, Takeda J, Yano H, Yamada Y, Bell GI, et al

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