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The historical trend and seasonal effect in the mode were adjusted using a linear predictor and a Fourier series of sine and cosine terms, respectively

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In these 3 trials, the percentage of patients who were depression-free (did not have an episode of MDD) at the end of treatment was significantly higher in the bupropion group than in the placebo group: 81.4% vs

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Instead, it offers something more specific a different approach built around tobacco itself rather than modification

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