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Oxidative stress can result either from the excessive production of reactive oxygen species, which might be anticipated at times of glutamatergic over-activity, or from a reduction in oxidative defences, and can damage cell structures

They don't work through insulin or inflammation they act on the hypothalamic-pituitary-gonadal (HPG) axis itself

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Always verify current regulatory and clinical-trial status through primary sources such as the FDA, ClinicalTrials.gov, and PubMed.