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Unusual symptoms such as acne-like skin reactions or hypokalaemia (low potassium) during initial high-dose treatment are rare but should prompt medical consultation

In the Diabetes Prevention Program Outcomes Study (DPPOS, N=1,800), metformin use for a mean of 12.7 years was associated with a 13% prevalence of B12 deficiency versus 5.4% in the placebo group (P 9%) impairs wound healing regardless of peptide use [4]

Luo, X., Li, R

However, Vitamin C may contribute to general well-being, which could indirectly influence mood in some individuals