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(d) Ferroptosis-targeted therapeutic strategies and future perspectives, summarizing current ferroptosis-directed interventions that encompass pharmacological agents, gene therapy, and cell-based treatments, and examining both the challenges and opportunities of their clinical translation

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The use of Drosophila bring to the study of oxidative liver injury many advantages, including ease of genetic manipulation, availability of genetic mutants and constructs, ease of germ-free generation, relatively short lifespan, amenability to high-throughput screening, and overall cost relative to murine models 40

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