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The combined effects can produce excessive sedation or unpredictable interactions

In this study, metformin did not alter oxidative phosphorylation or glycolysis in normal non-cancer rectal tissue biopsies, importantly suggesting that the anti-metabolic effects of metformin may be tumour tissue-specific, which supports its potential utility as a radiosensitiser in rectal cancer

Research Use Only Not for Human Consumption

The bioavailability difference only matters for oral, nasal, and topical routes of administration

KPV controls inflammation that might otherwise slow healing

Roberts KG, Li Y, Payne-Turner D, Harvey RC, Cheng J, Zhang J, Song G, Y-L Y, Santiago-Morales N, Pei D, Cheng C, Ma J, S-C C, Rusch M, Gupta P, Devidas M, I-M C, Larsen EC, Winick NJ, Carroll WL, Heerema NA, Carroll AJ, M Gastier-Foster JM, Raetz EA, C-H P, Jeha S, Downing JR, Paietta E, Kornblau SM , Marcucci G, Bloomfield C, Gerhard DS, Loh ML, Willman CL, Hunger SP, Mullighan CG