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In summary, the aforementioned nanodrug delivery systems, by achieving specific responses to MMP-rich microenvironmental stimuli, controlled drug release and multiple mechanisms of action (such as enhancing the permeability and retention effect, triggering immune responses, synergizing with radiotherapy, inhibiting invasion and crossing the BBB), provide powerful novel strategies for precisely targeting and modulating MMP-related key pathological processes in GBM (Table SIV)

In fact, the studies examining BPC-157 in oncology contexts have generally shown protective or neutral effects

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Silibinin declines blue light-induced apoptosis and inflammation through MEK/ERK/CREB of retinal ganglion cells

Sub-chronic administration of stable GIP analog in mice decreases serum LPL activity and body weight