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Yee PP, Wei Y, Kim SY, Lu T, Chih SY, Lawson C, et al

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Nuclear factor erythroid 2-related factor 2 (Nrf2), a critical modulator of antioxidant signaling, regulates the transcription of various genes coding antioxidant enzymes and cytoprotective proteins [17]

The salvage pathway, which is predominant in mammals, recycles NAM derived from food intake and as a byproduct of NAD + consuming enzymes such as silent information regulator 2 proteins (Sirtuins), poly (ADP-ribose) polymerase 1 (PARP1), CD38 and Sterile Alpha and TIR Motif Containing 1 (SARM1)