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Gastroenterology (2020) In Press

When fish perceive a stressor, the hypothalamus secretes corticotropin-releasing hormone (CRH), which stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH)

This suggests that an imbalance in the NGF/TrkA/p75NTR pathway may be associated not only with the aberrant auditory perception in tinnitus but also with the accompanying affective comorbidities