Ames BN, Cathcart R, Schwiers E, Hochstein P
Week 34 Many patients notice: Enhanced brightness Reduction in dullness More even complexion Week 58 Visible improvements often become more apparent: Better skin clarity Reduction in tanning Improved radiance Month 23 Most patients experience: Noticeable brightening Improved skin quality Better pigmentation control Month 36 Peak results may become evident with continued treatment and maintenance
The 2016 Noh investigation in International Journal of Molecular Sciences documented novel anti-melanogenesis properties of PDRN, identifying inhibition of microphthalmia-associated transcription factor (MITF) as the mechanism by which PDRN reduces melanin synthesis
All of the studies used both in vivo and some form of in vitro methods of data collection in order to observe different treatment effects, allowing for biomechanical, functional (use of AFI index and load to failure), macroscopic and microscopic histological analysis
But these may cause irritation, redness and burning sensation in the skin folds
Neuroprotective, AntiAmyloidogenic and Neurotrophic Effects of Apigenin in an Alzheimer's Disease Mouse Model. Molecules 18: 99499965
