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SCFAs and serotonin are microbe-derived chemical compounds that have the potential to regulate local vagal routes via portal circulation and send signals to the brain through the enteric nervous system (ENS) and vagal afferent routes (268, 269)

It typically leads to structural modification

Selective neuronal vulnerability to oxidative stress in the brain

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They involve the complexity of the whole animal thus making the monitoring of in vivo systems quite difficult