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Clin Exp Immunol (2008) 154(2):22434

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Sleep deprivation increases IL-4 and IL-13 (Th2 cytokines that drive allergic inflammation) while decreasing IL-10 and IFN-gamma (anti-allergic cytokines)

Glucocorticoids, including cortisol, can regulate MMP-9 (79), therefore, it is possible that this negative relationship is related to chronic cortisol dysregulation in PTSD

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Individual skin response Some people respond faster to treatments, while others need slower, gentler protocols due to sensitivity or hormonal triggers