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31 Since the 2021 review, one more RCT has been published that compared oral B12 alone, 25 g per day (form not reported), or with folate (800 g per day) versus no supplements for 6 months in patients with mild cognitive impairment

Trials continue even after approval

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3 Vitamin B12 deficiency The haematological effects of B12 deficiency are the same as for folate deficiency, and are characterised by macrocytic anaemia (with abnormally large red blood cells)

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