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Alzheimers disease (AD), the most common type of dementia in the elderly, is a serious neurodegenerative disease which is associated with progressive cognitive deterioration, such as memory loss and logical reasoning ability decline [8]

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Subsequent investigation shows that mTOR signaling dynamically controls Treg cell migration and stability in inflammatory settings ( AMPK acts as an energy-sensing counterbalance to mTOR (80)

There is a strong line of research implicating MMP-9 in sleep and memory consolidation processes and MMP-9 is upregulated during contextual fear learning (76)

3 The application of PEFs technology in cancer treatment 3.1 Pancreatic cancer Pancreatic cancer stands as one of the malignancies most frequently targeted by PEFs therapy, which not only significantly suppresses tumor progression but also remodels the immunosuppressive TME, thereby preventing recurrence and metastasis

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