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HbA1c falls where it starts high, and the glucose effect saturates below the weight dose: doubling from 1.0 to 2.0 mg added only about 0.2 points of HbA1c while still adding weight loss
Andersson, Emmanuel Shapira, Biochemical and clinical response to hydroxocobalamin versus cyanocobalamin treatment in patients with methylmalonic acidemia and homocystinuria (cblC), The Journal of Pediatrics, Volume 132, Issue 1, January 1998, Pages 121-124, ISSN 0022-3476, Okuda K, Yashima K, Kitazaki T, Takara I
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generally, if its close to the next dose, skip the missed dose (do not double up doses)
