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5 Many of the clinical benefits of NAC are based on its ability to correct or prevent GSH depletion

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Research suggests supplementation (including 300 mg/day orally) might improve liver enzyme labs in people with fatty liver disease (Healthline)

Thermal hyperalgesia was evaluated using the Hargreaves test, which measures paw withdrawal latency (PWL) in response to a focused infrared (IR) heat source applied to the plantar surface of the hind paw

This leads to the dislocation of apical and basolateral transporters (e.g., Na/K-ATPase) resulting in a leaky epithelium