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A reduction in the production of SCFAs, particularly butyrate, due to reduced populations of beneficial intestinal bacteria compromises the integrity of the intestinal barrier and promotes inflammation ( Table 1 ) [89, 90]

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A single-blind, randomized, controlled trial (NCT01964001) in patients with primary HCC found that CoQ10 supplementation for 12 weeks post-surgery significantly improved antioxidant capacity and reduced oxidative stress and inflammation levels

Cell Host Microbe 24 , 857865.e854 (2018)

Postmortem investigations of neuronal and glial cells in MDD revealed neuronal atrophy, neuronal shrinkage, an increased density of microglia, a reduction in astroglial cells, impaired neurogenesis, a decrease in hippocampal volume, a decreased density of total glia and oligodendrocytes in the amygdala, and a depletion of oligodendrocytes [1]