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DYRK1B inhibition exerts senolytic effects on endothelial cells and rescues endothelial dysfunctions

in people with diabetes) are ongoing to assess the efficacy and durability of weight loss with 3.6 and 6 mg doses over 76 weeks (clinical trial numbers NCT06066515 and NCT06066528)

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Mar 2008;28(2):174-180

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age