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The two-hour half-life is a feature, not a limitation: it allows the pituitary to reset between doses, preventing the receptor downregulation and negative feedback loops associated with sustained GH elevation

10.1161/01.str.0000103140.52838.45 Stroke 150 XiongX

We know cortisol is a direct neurotoxin, likely being a risk factor for Alzheimers disease

However, traditional breeding limits the genetic improvement of sheep breeding in the short term

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