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USA 112 , 1385013855 (2015)

Visser, J

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in the Journal of Investigative Dermatology (2008) demonstrated that KPV inhibits pro-inflammatory cytokine production, including tumor necrosis factor-alpha (TNF-) and interleukin-1 beta (IL-1)

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The mechanisms most cited in the literature are promotion of angiogenesis (new blood-vessel formation, linked to VEGFR2 signaling), modulation of growth-factor and nitric-oxide pathways, and interaction with the gut-brain axis